Neural replacement cells can be derived from stem cell compartments in adult brain tissues where estrogen receptor beta (ERβ) may stimulate their growth after injury. During growth, ERβ can exhibit a non-classical function as a plasma membrane receptor involved in intracellular signaling cascades. When acting at the membrane, ERβ can associate with caveolin to effect calcium signaling, protein localization and function, cell differentiation, migration, and survival, as well as gene transcription. Most membrane destined proteins are processed through the endomembrane pathway, which means they are targeted into the endoplasmic reticulum and Golgi apparatus. However, little is known about how ERβ is processed. Preliminary observations have indicated extra-nuclear ERβ in cytoplasmic organelles such as the endoplasmic reticulum. Therefore, we hypothesize that ERβ is targeted into the endoplasmic reticulum and Golgi apparatus, before transport to the membrane. Understanding how ERβ is processed before transport to the membrane may identify novel interactions that are crucial in developing potential target modifiers that enhance neural replacement.
McLeod, Christopher; Pearce, Virginia; Park, Yong; and Simpkins, James, "Extra-Nuclear Estrogen Receptor β" (2010). Research Appreciation Day. Paper 2.