Abstract Title

WHERE LESIONS COLLIDE: THE SELLA TURCICA

Presenter Name

Ashley Windham

Presentation Type

Poster

Purpose (a):

Collision tumors are neoplasms involving two types of histology in one mass. Collision tumors of the sella turcica are a rare species of brain tumors and the information is sparse. Most commonly, the tumors are comprised of more than one type of adenoma. There has been no published case of a collision tumor involving a neuroendocrine and adenomatous histology, which we present a case here. The purpose of this case report was to review the differential diagnosis of sellar and parasellar masses. Also, we aimed to hypothesize about the etiology of collision tumors in the sella and present this unique case of a collision tumor.

Methods (b):

A case report of one pituitary microadenoma of a 72 year old Caucasian female who presented with eye pain and headaches. The tumor was removed transsphenoidally and histopathologically categorized.

Results (c):

The tumor was histologically diagnosed as a collision tumor involving a neuroendocrine tumor with a pituitary adenomatous component. Immunohistochemistry revealed a strongly positive synaptophysin stain with a weakly positive Ki-67 in the spindle cell regions. Adrenocorticotropic hormone, prolactin, growth hormone, luteinizing hormone, follicle-stimulating hormone, glial fibrillary acidic protein, CAM 5.2 and p53 stains were are grossly negative.

Conclusions (d):

Collision tumors are a rare phenomenon involving the sella turcica. A review of literature reveals very few collision tumors as well as no publication with a neuroendocrine tumor colliding with a pituitary adenoma. This case adds to the already extensive differential diagnosis for sella turcica masses.

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WHERE LESIONS COLLIDE: THE SELLA TURCICA