The Study of 5-HTTLPR and rs25531 to Identify Allele Variants of Offenders Charged with Driving While Intoxicated and Driving Under the Influence.

Ravali Gudep, University of North Texas Health Science Center at Fort Worth

Abstract

Serotonin, also referred to as 5-hydroxytryptamine, is a neurotransmitter which plays a critical role in behavioral and genetics studies. The 5-hydroxytryptamine-transporter-linked polymorphic region (5-HTTLPR), present in the promoter region of the serotonin transporter gene, can have varying number of repeats. In addition, a single nucleotide polymorphism (SNP), rs25531, is present within the repeats. A novel assay was designed to genotype 5-HTTLPR and its SNP variant in a single capillary electrophoretic injection. A total of 100 samples received from the Center for Alcohol and Drug Studies at San Diego State University Research Foundation were successfully genotyped.