Date of Award

5-1-2008

Degree Type

Restricted Access Thesis

Degree Name

Master of Science

Field of Study

Primary Care Clinical Research

Department

Graduate School of Biomedical Sciences

First Advisor

Roberto Cardarelli

Second Advisor

Sejong Bae

Third Advisor

Richard Virgilio

Abstract

AbdulRahim, Nashila, Interleukin-6 and its Relationship to Coronary Artery Calcium Burden- North Texas Healthy Heart Study. Master of Science (Primary Care Clinical Research), May, 2008, pp., 7 tables, 5 figures, bibliography, 73 titles. Atherosclerosis is highly associated with increased serum inflammatory markers. Coronary artery calcium (CAC) burden has allowed researchers to have a non-invasive proxy measure of atherosclerosis. We hypothesized that interleukin-6 (IL-6), after controlling for CV risk factors, would be associated with CAC scores, and this association will be modified by race/ethnicity. 344 subjects were recruited. IL-6 concentrations were measured, and computed tomography was used to calculate CAC scores. After accounting for age, gender, race, smoking, hypertension, diabetes, and cholesterol, a one-unit increase in IL-6 concentration is associated with 1.03 greater odds of an abnormal calcium score (OR: 1.03, 95% CI: 0.98, 1.07). Race/ethnicity did not modify this association. IL-6 did not prove to be a simple clinical marker of CAC.

Comments

AbdulRahim, Nashila, Interleukin-6 and its Relationship to Coronary Artery Calcium Burden- North Texas Healthy Heart Study. Master of Science (Primary Care Clinical Research), May, 2008, pp., 7 tables, 5 figures, bibliography, 73 titles. W 4.5 A136I 2008

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