Date of Award
Winter 12-2009
Degree Type
Internship Practicum Report
Degree Name
Master of Science
Field of Study
Clinical Research Management
Department
Graduate School of Biomedical Sciences
First Advisor
Dr. Rustin Reeves
Abstract
Purpose: To evaluate bone graft substitutes used in spine fusion surgery and determine the feasibility of studying the use of adult stem cells.
Hypothesis: Using a well designed, randomized clinical trial to compare bone graft substitutes used in spine fusion surgery will help determine the best alternative to autologous bone graft.
Design: Retrospective data on two bone graft substitutes will be evaluated. A protocol for studying stem cells in spine fusion will be drafted and the feasibility of implementing the trial will be analyzed.
Results: It is difficult to design a randomized clinical trial to investigate a new surgical technique. The lack of standardization among spine surgeons makes it difficult to control for confounding variables.
Recommended Citation
Hukic, S.
,
"Bone Marrow Aspirate vs. Bone Morphogenetic Protein (rhBMP-2) in Multilevel Adult Spinal Deformity Surgery and the Feasibility of Using Adult Mesenchymal Stem Cells." Fort Worth, Tx: University of North Texas Health Science Center;
(2009).
http://digitalcommons.hsc.unt.edu/theses/48