Date of Award

12-1-1998

Degree Type

Restricted Access Thesis

Degree Name

Master of Science

Field of Study

Biomedical Sciences

Department

Graduate School of Biomedical Sciences

First Advisor

Eugene Quist

Second Advisor

Glenn Dillon

Third Advisor

Michael Forster

Abstract

Jester, Lara A., The Inositol Tetrakisphosphate-Stimulated Calcium Transporter in Cardiac Membranes. Master of Science (Biomedical Sciences), December 1998, 61 pp., 13 illustrations, references, 49 titles. Regulation of Ca2+ fluxes across the sarcolemma and sarcoplasmic reticulum (SR) are critical for regulation of calcium across the myocardial membranes. Studies were performed on the InsP4 stimulated Ca2+ transporter from both canine and bovine heart tissue to determine the location and ionic conditions under which InsP4 stimulated Ca2+ transporter works most efficiently. The results indicated that the InsP4 stimulated Ca2+ transporter is present in the sarcolemma, and is functional under conditions that are physiologically relevant. These findings may compliment future in vivo or in situ studies that will further examine the role of the InsP4 stimulated Ca2+ transporter in the heart.

Comments

Jester, Lara A., The Inositol Tetrakisphosphate-Stimulated Calcium Transporter in Cardiac Membranes. Master of Science (Biomedical Sciences), December 1998, 61 pp., 13 illustrations, references, 49 titles. W 4.5 J58I 1998

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