Date of Award

Spring 5-2010

Degree Type

Thesis

Degree Name

Master of Science

Field of Study

Primary Care Clinical Research

Department

Graduate School of Biomedical Sciences

First Advisor

Dr. Kimberly Fulda

Abstract

Cardiovascular disease is a significant cause of morbidity and mortality in autoimmune patients. This study strives to: 1) determine if autoimmune disease is associated with a coronary calcium score (CAC) > 0; 2) determine if autoimmune disease is associated with interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen levels; and 3) determine if Il-6, CRP, and fibrinogen mediate the relationship between autoimmune disease and CAC. This is a crosssectional study using data obtained from the North Texas Healthy Heart study. Autoimmune disease was present in 118 individuals. Autoimmune status was not significant in predicting presence of CAC > 0, IL-6, or CRP levels in the adjusted model. Autoimmune status, however, was a significant predictor of fibrinogen levels. IL-6, CRP, and fibrinogen did not act as mediators as there was not a significant change in the association between autoimmune status and CAC when these inflammatory markers were added to the model.

Share

COinS