Date of Award
Restricted Access Professional Report
Master of Science
Field of Study
Graduate School of Biomedical Sciences
Escobedo, Israel, Validation of the Laboratory Information Systems Applications (LISA): Kinship Analysis Module. Master of Science (Biomedical Sciences), December 2008, 155 pp., 10 tables, 21 figures, references, 34 titles. The Laboratory Information Systems Applications (LISA) is a LIMS system designed for the management and analysis of genetic data from large scale investigations of human identification. The validation study evaluated the pedigree construction and analytical tools of the Kinship Analysis module. The genetic data from old paternity cases was used to construct pedigrees under several scenarios that stimulate situations involving a missing child/parent. Each pedigree was analyzed to obtain a KI that measures the strength of the observed genetic evidence for an association made between a missing/deceased individual and a family reference pedigree to make identification. A common distribution of the number of observations per range of the 1n KI was observed in all scenarios. A concordance and reproducibility study was conducted for eight families using a validated kinship analytical program. LISA has the potential of becoming an efficient tool for human identification despite the limitations of the software.
"Validation of the Laboratory Information Systems Applications (LISA): Kinship Analysis Module" Fort Worth, Tx: University of North Texas Health Science Center;