Date of Award

5-1-2014

Degree Type

Thesis

Degree Name

Master of Science

Field of Study

Forensic Genetics

First Advisor

Deanna Cross

Abstract

OMT is a treatment for patients with CLBP. It is underutilized partially because there is still skepticism regarding efficacy and no clear mechanism of action has been defined.

Data previously collected from a CLBP clinical study was used to investigate genotypic and/or phenotypic characteristics associated with OMT pain reduction. Polymorphisms in IL-8 (rs2227543), GCH1 (rs998259), and LARGE (rs240070) were associated with treatment response defined as at least 30% pain reduction (α≤0.05). An intergenic interaction was observed in GCH1 (rs998259/rs3783641). A multivariate model which included the GCH1 polymorphisms was able to account for ~76% of variability in response to OMT. This study successfully demonstrated an association between genetics and response to OMT.

Comments

Richardson, Kayla K., Determination of Genetic Factors Associated with Response to Osteopathic Manipulative Treatment (OMT) in Individuals with Chronic Lower Back Pain (CLBP). Master of Science (Forensic Genetics), May, 2014, 44pp., 15 tables, 8 figures, references, 48 titles. Available May 2015

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