Date of Award
Master of Science
Field of Study
Graduate School of Biomedical Sciences
Joseph E. Warren
John V. Planz
Raghu R. Krishnamoorthy
It is common in the forensic science community to have standardization and uniformity in all laboratory processes. The method for the determination of a minimum detection threshold or synonymously an analytical threshold for genetic analysis is not uniform across forensic labs. Variation amongst the methods in DNA testing by forensic laboratories leads to variations in the results of the DNA testing.
The results of this study show a method using DNA sample types versus non-DNA sample types will better reflect the effects of baseline noise that may be encountered in forensic casework samples. In addition, there is a need for a calculation method to be designated as an appropriate tool in determining analytical thresholds. More studies on baseline noise and methods in distinguishing analytical thresholds will help in the determination of the most appropriate calculation method to be used across all forensic laboratories.
Malone, A. N.
"Evaluating Noise and the Implications of Methodology in the Analytical Threshold Designation for Forensic Genetic Analysis" Fort Worth, Tx: University of North Texas Health Science Center;
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