Date of Award

8-1-2015

Degree Type

Thesis

Degree Name

Master of Science

Field of Study

Biomedical Sciences

Department

Graduate School of Biomedical Sciences

First Advisor

Rebecca L. Cunningham

Second Advisor

Robert C. Barber

Third Advisor

Weiming Mao

Abstract

Obstructive sleep apnea (OSA) is increasingly implicated in neurodegenerative diseases. Evidence points to OSA as contributing to inflammation similar to inflammation observed in neurodegeneration. The chronic intermittent hypoxia (CIH) experienced by OSA patients may be an early contributing factor to chronic inflammation that leads to neurodegeneration.

Experiments in this study identify circulating biomarkers affected by OSA and their early impact on neurodegeneration. In the first experiment, oxidative stress and inflammation were observed to increase in male rats exposed to CIH. In the second set of experiments, inflammation within brain nuclei implicated in the onset of Parkinson’s disease and Alzheimer’s disease were correlated to circulating OS elevated by CIH.

Comments

Snyder, Brina D., The Effects of Chronic Intermittent Hypoxia on Oxidative Stress and Inflammation. Master of Science (Biomedical Sciences), August 2015, 85 pp., 6 tables, 13 illustrations, bibliography, 155 titles. Available August 2016.