Title

Polymorphism of Y-STR haplotypes is governed by patrilineal ancestry combined with effects of male migration

Date of Award

12-1-2015

Degree Type

Thesis

Degree Name

Master of Science

Field of Study

Biomedical Sciences

Department

Graduate School of Biomedical Sciences

First Advisor

Ranajit Chakraborty

Second Advisor

John V. Planz

Abstract

This study examined geographic origins of Y-haplogroups and effects of migration using Y-STR haplotype databases compiled from the literature. Accuracy of haplogroup prediction was analyzed by varying the number of loci in haplotype definitions and by including rapidly mutating Y-STRs. Lastly, haplogroup diversities of populations were analyzed with respect to evolutionary history/size of populations and effects of admixture.

These analyses demonstrated: a) haplotype definitions with more loci increased haplogroup prediction accuracy; b) older populations did not negatively impact haplogroup prediction; c) including rapidly mutating loci as part of the haplotype-definition had minimal impact on haplogroup prediction and inferring population clustering, but had moderate impact on Network analysis; and d) haplogroup diversities increased with male admixture.

Comments

Nolan, Michael. Polymorphism of Y-STR haplotypes is governed by patrilineal ancestry combined with effects of male migration. Master of Science (Biomedical Sciences, Molecular Genetics) September, 2015, 40 pp., 23 tables, 4 figures, bibliography, 35 titles. Available December 2016.

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