Departmental Affiliation and City, State, Zip for All Authors

Jennifer Portillo, Department of Chemistry and Biochemistry, Northridge, CA, 91330; Mariana Rodriguez, Department of Biology, San Antonio, TX, 78209; Robert Luedtke, Department of Pharmacology and Neuroscience, Fort Worth, TX, 76107

Scientific Abstract

Neuropsychiatric diseases involve the dysregulation of dopamine and serotonin receptors. The symptoms present in those patients can be studied using the hallucinogenic drug 2,5-dimethoxy-4-iodoamphetamine (DOI) which prompts a head-twitch response (HTR) in mice. The purpose of this experiment was to determine the behavioral and genetic variations among 7 different inbred mice strains after inoculation of DOI. The mice were injected with DOI and the HTR was quantitated visually for a period of 30 minutes. The DBA/2J and DBA/1J mice presented the highest number of HTR to the DOI administration. Although DBA/2J and DBA/2NCrl are genetically similar, DBA/2J mice had a higher response to DOI than DBA/2NCrl mice. One difference between these two similar strains is a single polymorphism in the Trace Amine-Associated Receptor 1 (TAAR1) in the DBA/2J mice. Also, it was demonstrated that dopamine D_3 receptor selective compounds reduce the HTR in DBA/2J mice.

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INBRED MICE SURVEY: HEAD-TWITCH RESPONSE TO HALLUCINOGENIC DRUG

Neuropsychiatric diseases involve the dysregulation of dopamine and serotonin receptors. The symptoms present in those patients can be studied using the hallucinogenic drug 2,5-dimethoxy-4-iodoamphetamine (DOI) which prompts a head-twitch response (HTR) in mice. The purpose of this experiment was to determine the behavioral and genetic variations among 7 different inbred mice strains after inoculation of DOI. The mice were injected with DOI and the HTR was quantitated visually for a period of 30 minutes. The DBA/2J and DBA/1J mice presented the highest number of HTR to the DOI administration. Although DBA/2J and DBA/2NCrl are genetically similar, DBA/2J mice had a higher response to DOI than DBA/2NCrl mice. One difference between these two similar strains is a single polymorphism in the Trace Amine-Associated Receptor 1 (TAAR1) in the DBA/2J mice. Also, it was demonstrated that dopamine D_3 receptor selective compounds reduce the HTR in DBA/2J mice.

Manuscript Number

1051