Date of Award

Spring 5-2009

Degree Type


Degree Name

Master of Public Health


School of Public Health

First Advisor

Dr. Sumihiro Suzuki


Treatment outcomes of 28 high risk TKA PJI patients treated with either debridement, six weeks I.V. antimicrobial therapy and prosthesis retention, or same treatment with oral chronic suppressive therapy, to ascertain the effectiveness of oral chronic suppressive therapy were retrospectively reviewed in this study. The 2-year cumulative probability of failure for oral suppressive therapy was 7% (95%CI: 0.04 to 27.5) compared to 42% (95%CI: 17.7 to 66.07) for the control group. Oral suppressive therapy was significantly different than control (P= 0.033). This study underscores the importance of combining oral suppressive therapy in select patients with débridement and six weeks I.V. antimicrobial therapy.