Date of Award


Degree Type


Degree Name

Master of Science

Field of Study

Forensic Genetics


Graduate School of Biomedical Sciences

First Advisor

Joseph E. Warren

Second Advisor

John V. Planz

Third Advisor

Raghu R. Krishnamoorthy


It is common in the forensic science community to have standardization and uniformity in all laboratory processes. The method for the determination of a minimum detection threshold or synonymously an analytical threshold for genetic analysis is not uniform across forensic labs. Variation amongst the methods in DNA testing by forensic laboratories leads to variations in the results of the DNA testing.

The results of this study show a method using DNA sample types versus non-DNA sample types will better reflect the effects of baseline noise that may be encountered in forensic casework samples. In addition, there is a need for a calculation method to be designated as an appropriate tool in determining analytical thresholds. More studies on baseline noise and methods in distinguishing analytical thresholds will help in the determination of the most appropriate calculation method to be used across all forensic laboratories.


Malone, Ashley. Evaluating Noise and the Implications of Methodology in the Analytical Threshold Designation for Forensic Genetic Analysis. Master of Science (Biomedical Sciences, Forensic Genetics). August 2015. 34 pages, 7 tables, 12 figures, references, 18 titles. Available August 2016.