Date of Award

5-1-2015

Degree Type

Thesis

Degree Name

Master of Science

Field of Study

Integrative Physiology

Department

Graduate School of Biomedical Sciences

First Advisor

Ann M. Schreihofer

Second Advisor

J. Thomas Cunningham

Third Advisor

Derek Schreihofer

Abstract

Like obese humans, obese Zucker rats (OZR) develop hypertension and impaired baroreflexes. In adult OZR, brainstem nucleus tractus solitarius (NTS) becomes less responsive to baroreceptor inputs. We hypothesized NTS neurons of male OZR undergo abnormal neuroplasticity (ΔFosB expression) versus lean Zucker rats, and these changes would be absent in females with normal baroreflexes. We saw increased NTS ΔFosB at 7-8 wks in male but not female OZR. Unlike male OZR, females had normal baroreflexes and NTS function. We were unable to identify the NTS neurons with ΔFosB. They do not project to caudal ventrolateral medulla (baroreflex pathway), are not A2 neurons, and do not make nitric oxide. These data suggest the NTS of male OZR undergoes abnormal neuroplasticity with the onset of cardiovascular deficits and females are protected. Future studies will identify the NTS neurons and determine what causes changes in them to contribute to impaired cardiovascular regulation in OZR.

Comments

Fu, Guangchao (Jeffery), Observations of impaired autonomic regulation of arterial pressure in obese Zucker rats: focus on changes in the nucleus of the solitary tract. Master of Science (Integrative Physiology and Anatomy), April, 2015, 58 pp, 25 figures, bibliography, 67 titles.

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