Date of Award


Degree Type

Internship Practicum Report

Degree Name

Master of Science

Field of Study

Clinical Research Management


Graduate School of Biomedical Sciences

First Advisor

Jerry W. Simecka

Second Advisor

Dong-Ming Su

Third Advisor

Stephen O. Mathew


To reduce post-operative pain correlates such as opioid consumption and length of stay, a novel pain management protocol has been utilized for laparoscopic appendectomy and laparoscopic cholecystectomy. Research was performed on a retrospective patient population who were given local anesthetic for pain management, specifically liposomal bupivacaine, also known as Exparel. The objective was to determine if using the most recent protocol utilizing Exparel had any effect on pain correlates such as opioid consumption or post-operative or total length of stay. Results showed that the use of the most recent Exparel protocol results in a statistically significant decrease in opioid consumption. Results also show that the pain management protocol used had no significant effect on post-operative or total length of stay.


Newman, Pete, Pain Management After Appendectomy and Cholecystectomy: An Innovative Protocol Using Exparel. Master of Science (Clinical Research Management), November, 2017. 87 pp., 9 tables, 14 figures, references, 40 titles. Available worldwide December 2018