Date of Award


Degree Type


Degree Name

Master of Science

Field of Study

Pharmacology and Neuroscience


Graduate School of Biomedical Sciences

First Advisor

Nathalie Sumien


Metabolic acidosis is a condition in which there is a disruption in the acid/base balance of the body due to an excess of hydrogen ions. This study investigated if in vivo metabolic acidosis lead to brain dysfunction, whether these potential effects were exacerbated with age, and if brain alterations were associated with changes in acid-sensing ion channel (ASIC) 1 and 2a expression. We found that mild chronic acidosis induced by ammonium chloride supplementation resulted in decreased weight in old mice, reversed age-related impairments in motor and cognitive function, and improved spatial learning and memory of young mice. No major alterations were observed in expression of ASIC1 or 2a.


Kindle, Robbyn S., Metabolic Acidosis-Induced Alterations on motor and cognitive function and acid-sensing ion channels 1 and 2a in the brains of young and aged male mice, Master of Science (Pharmacology and Neuroscience), June, 2015, 61 pp., 2 tables, 20 figures, bibliography, 61 titles.